“Medications that interfere with prostaglandins-production or activity are the best treatments,” Dr. Polaneczky says. Non-steroidal anti-inflammatory drugs (NSAIDs), for example, target and reduce the amount of prostaglandins that your body makes, which will make your cramps less severe, according to the American Congress of Obstetrics and Gynecologists (ACOG). According to Dr. Polaneczky, Motrin, Advil, or Aleve will probably be effective for most people, but you might have to try a few different types of NSAIDs to find one that works for you. “You can switch to a different class and you might have more efficacy, because they all act on different spots in the prostaglandin-production pathways,” she says.
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